Article

ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: a human and experimental study

2025-09-14

Abstract excerpt

<h4>ABSTRACT</h4> Meningeal inflammation, as a clinical feature of multiple sclerosis (MS), is associated with worse clinical disease outcomes. In both relapsing and secondary progressive MS and the experimental autoimmune encephalomyelitis (EAE) MS model, the meninges have been found to contain ectopic lymphoid follicles enriched with B cells. The metabolic requirement of meningeal B cell function in MS or EAE i...

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Literature Corpus work: 01db7da3-067f-54c2-9289-600fea83c0db
DOI: 10.1101/2025.09.09.674821

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