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Article

Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.

Journal of neurochemistry - 1 Feb 2012

Thompson Misty, Marecki John C, Marinesco Stephane, Labrie Viviane, Roder John C, Barger Steven W, Crow John P

Abstract excerpt

D-serine is an endogenous neurotransmitter that binds to the NMDA receptor, thereby increasing the affinity for glutamate, and the potential for excitotoxicity. The primary source of D-serine in vivo is enzymatic racemization by serine racemase (SR). Regulation of D-serine in vivo is poorly understood, but is thought to involve a combination of controlled production, synaptic reuptake by transporters, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22117694
DOI: 10.1111/j.1471-4159.2011.07601.x
PMCID: PMC3398808

Genes

SOD1
DAO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.PMID 22117694Read ↗

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine modelSemantic proximity Read ↗

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Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Semantic proximity Read ↗

Postsynaptic serine racemase regulates NMDA receptor functionSemantic proximity Read ↗

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.Semantic proximity Read ↗

A new type of blood-brain barrier aminoacidopathy underlies metabolic microcephaly associated with SLC1A4 mutations.Semantic proximity Read ↗

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D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?Semantic proximity Read ↗

SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative DisordersSemantic proximity Read ↗

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