Article

SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders

2025-01-31

Abstract excerpt

The solute carrier family 1 member 4 (SLC1A4) gene encodes a neutral amino acid transporter, also referred to as alanine-serine-cysteine transporter 1, ASCT1, that helps maintain amino acid balance in the brain and periphery. In the brain, SLC1A4 plays important roles in transporting levo(L) and dopa(D) isomers of serine. L-serine is required for many cellular processes, including protein and sphingolipid synthesi...

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Literature Corpus work: 72ab8761-2f3e-521c-8e30-273a6d00f54a
DOI: 10.20944/preprints202501.2307.v1

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