Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.

The EMBO journal - 19 Sept 2007

Sasabe Jumpei, Chiba Tomohiro, Yamada Marina, Okamoto Koichi, Nishimoto Ikuo, Matsuoka Masaaki, Aiso Sadakazu

Abstract excerpt

Excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). More recently, glial involvement has been shown to be essential for ALS-related motoneuronal death. Here, we identified an N-methyl-D-aspartate (NMDA) receptor co-agonist, D-serine (D-Ser), as a glia-derived enhancer of glutamate (Glu) toxicity to ALS motoneurons. Cell death assay indicated that primary spinal cord...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Induction
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neurons

Share to N-Methylaspartate

Share to Neuroglia

Share to p38 Mitogen-Activated Protein Kinases

Share to Racemases and Epimerases

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 17762863
DOI: 10.1038/sj.emboj.7601840
PMCID: PMC2230675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.PMID 17762863Read ↗

Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.Semantic proximity Read ↗

The Role of D-Amino Acids in Alzheimer’s DiseaseSemantic proximity Read ↗

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine modelSemantic proximity Read ↗

Pharmacological inhibition of D-serine biosynthesis improves hippocampal memory, prevents neuronal loss and enhances synaptic connectivity in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.Semantic proximity Read ↗

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related NeurodegenerationSemantic proximity Read ↗

Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.Semantic proximity Read ↗

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice.Semantic proximity Read ↗

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.Semantic proximity Read ↗

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.