Article

Aging-associated alternative splicing programs conserved between human and mouse tissues

2025-12-31

Abstract excerpt

Alternative splicing is a key gene regulatory process that diversifies the proteome and controls gene dosage. Previous studies have detected aging-associated splicing changes across various tissues. However, their use of bulk RNA-seq obfuscates the impacted cell-types and may confound cell-type proportion changes with cell-intrinsic ones. We present a framework that first assembles and maps alternative splicing ev...

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Literature Corpus work: ff3c3019-5dbb-58ec-850b-77d737786ebb
DOI: 10.64898/2025.12.30.697080

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