Article

Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries

2018-08-16

Abstract excerpt

Most human genes are alternatively spliced, allowing for a large expansion of the proteome.The multitude of regulatory inputs to splicing limits the potential to infer general principles from investigating native sequences. Here, we created a rationally designed library of >32,000 splicing events to dissect the complexity of splicing regulation through systematicsequence alterations. Measuring RNA and protein spli...

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Identifiers and source

Literature Corpus work: f6608abf-9d43-5ba4-a722-1091e4b4fe31
DOI: 10.1101/392605

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