Article

Mammalian aging involves genome-wide splicing degeneration leading to functional decline

2026-06-29

Abstract excerpt

Alternative splicing exhibits significant changes during development and aging, affecting the composition and variance in the transcriptome. However, it is unclear whether and how age-associated splicing dysregulation leads to functional consequences. Here, an integrative analysis of transcriptome data across mouse and human tissues revealed that aging is characterized by systematic deterioration of the fidelity o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e540c47-9145-5155-8ec0-33046663b74f
DOI: 10.64898/2026.06.26.734787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mammalian aging involves genome-wide splicing degeneration leading to functional declineDOI 10.64898/2026.06.26.734787Read

Alternative splicing in aging and longevity.Semantic proximity Read

The landscape of the alternatively spliced transcriptome remains stable during aging across different species and tissuesSemantic proximity Read

Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicingSemantic proximity Read

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read

Aging-associated alternative splicing programs conserved between human and mouse tissuesSemantic proximity Read

Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases.Semantic proximity Read

Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human AgingSemantic proximity Read

Aging is associated with a systemic length-driven transcriptome imbalanceSemantic proximity Read

Splicing accuracy varies across human introns, tissues and ageSemantic proximity Read

The emerging role of alternative splicing in senescence and agingSemantic proximity Read

Causally measuring aging and rejuvenation through transcriptomic damageSemantic proximity Read

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer’s DiseaseSemantic proximity Read