Article

Splicing accuracy varies across human introns, tissues and age

2023-03-30

Abstract excerpt

Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigated mis-splicing using RNA-sequencing data from ~14K control samples and 42 human body sites, focusing on split reads partially mapping to known transcripts in annotation. We show that mis-splicing occurs at different rates across introns and tissues and t...

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Literature Corpus work: 676eaa06-04c0-5fd6-b1e6-595e9bad8086
DOI: 10.1101/2023.03.29.534370

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