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Article

A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures.

Genome research - 1 Aug 2023

Mao Shulin, Su Jiayu, Wang Longteng, Bo Xiaochen, Li Cheng, Chen Hebing

Abstract excerpt

Accurately measuring biological age is crucial for improving healthcare for the elderly population. However, the complexity of aging biology poses challenges in how to robustly estimate aging and interpret the biological significance of the traits used for estimation. Here we present SCALE, a statistical pipeline that quantifies biological aging in different tissues using explainable features learned from...

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PMID: 37524436
DOI: 10.1101/gr.277491.122
PMCID: PMC10547252

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