Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases.

Scientific reports - 19 Jul 2018

Wang Kun, Wu Di, Zhang Haoyue, Das Avinash, Basu Mahashweta, Malin Justin, Cao Kan, Hannenhalli Sridhar

Abstract excerpt

Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a comprehensive map of age-associated splicing changes across multiple tissues. Here, we generate such a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genetic Predisposition to Disease

Share to Organ Specificity

Share to RNA Splicing

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 30026530
DOI: 10.1038/s41598-018-29086-2
PMCID: PMC6053367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases.PMID 30026530Read ↗

Aging-associated alternative splicing programs conserved between human and mouse tissuesSemantic proximity Read ↗

Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human AgingSemantic proximity Read ↗

Genetic dysregulation of gene expression and splicing during a ten-year period of human agingSemantic proximity Read ↗

An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)Semantic proximity Read ↗

The landscape of the alternatively spliced transcriptome remains stable during aging across different species and tissuesSemantic proximity Read ↗

The combination of differential expression and differential network connectivity analyses identifies RNA splicing and processing as common pathways altered with age across human tissuesSemantic proximity Read ↗

Tissue-specific impacts of aging and genetics on gene expression patterns in humansSemantic proximity Read ↗

Human pan-body age- and sex-specific molecular phenomena inferred from public transcriptome data using machine learningSemantic proximity Read ↗

Mammalian aging involves genome-wide splicing degeneration leading to functional declineSemantic proximity Read ↗

Tissue-specific impacts of aging and genetics on gene expression patterns in humans.Semantic proximity Read ↗

Histone mark age of human tissues and cellsSemantic proximity Read ↗

Splicing accuracy varies across human introns, tissues and ageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.