Article

Cell-specific RNA isoform remodeling in the aging mouse brain

2025-06-08

Abstract excerpt

Aging is associated with increases in risk of multiple chronic diseases and at the cellular level, with disruptions in RNA homeostasis. Single-cell transcriptomic studies have revealed RNA abundance heterogeneity across brain cell types but the more complex changes in RNA processing such as alternative splicing, isoform usage, transcription start and polyadenylation site selection remain uncharacterized. Here, we...

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Literature Corpus work: dd63c6ee-1055-5d51-96b4-6312daa4a974
DOI: 10.1101/2025.06.05.658133

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