Article

RNA splicing programs define tissue compartments and cell types at single cell resolution

2021-05-02

Abstract excerpt

More than 95% of human genes are alternatively spliced. Yet, the extent splicing is regulated at single-cell resolution has remained controversial due to both available data and methods to interpret it. We apply the SpliZ, a new statistical approach that is agnostic to transcript annotation, to detect cell-type-specific regulated splicing in > 110K carefully annotated single cells from 12 human tissues. Using 10x...

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Literature Corpus work: d175804f-115e-5078-9454-a50a871ff26a
DOI: 10.1101/2021.05.01.442281

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