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Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

2021-11-24

Abstract excerpt

<h4>Background</h4> Genome-wide association studies have discovered hundreds of common genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of susceptibility loci into biological mechanisms and targets for drug discovery remains challenging. Intersecting genetic and gene expression data has led to the identification of candidate genes. However, previously studied tissues ar...

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Literature Corpus work: ff1ffadc-aeec-5dab-8b8f-5f2b4e841bdc
DOI: 10.1101/2021.11.23.21266487

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