Article

Integrated single-cell atlas of human atherosclerotic plaques

2024-09-12

Abstract excerpt

Atherosclerosis, a major cause of cardiovascular diseases, is characterized by the buildup of lipids and chronic inflammation in the arteries, leading to plaque formation and potential rupture. The underlying causal immune mechanisms and alterations in structural cell composition and plasticity driving plaque progression remain incompletely defined. Recent advances in single-cell transcriptomics (scRNA-seq) have p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66d60061-2937-55d1-9399-6a452524d8cb
DOI: 10.1101/2024.09.11.612431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell atlas of human atherosclerotic plaquesDOI 10.1101/2024.09.11.612431Read

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisSemantic proximity Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Decoding the transcriptome of atherosclerotic plaque at single-cell resolutionSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read

Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq.Semantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosisSemantic proximity Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular EventsSemantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease.Semantic proximity Read

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.Semantic proximity Read