Article

Single-cell RNA-seq analysis of human coronary arteries using an enhanced workflow reveals SMC transitions and candidate drug targets

2020-10-27

Abstract excerpt

<h4>Background and Aims</h4> The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate plaque stability or other plaque phenotypes are not yet available. We sought to investigate the human atherosclerotic cellular environment using scRNA-seq to uncover potential therapeutic approaches. We aimed to make our workflow user-friendly, reproducible, and applicable to other diseas...

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Literature Corpus work: 921d2f4c-f29d-53fa-943c-b0d803b1a4e4
DOI: 10.1101/2020.10.27.357715

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