Article

Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease

2023-09-17

Abstract excerpt

<h4>Background</h4> Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. While over 250 genetic risk loci have been identified through genome-wide association studies, the specific causal variants and their regulatory mechanisms are still largely unknown, particularly in disease-relevant cell types like macrophages. <h4>Methods</h4> We util...

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Literature Corpus work: eaa3ad48-2366-5ddb-8e40-24aebca9ac0c
DOI: 10.1101/2023.09.14.557845

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