Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.

doi:10.1161/CIRCRESAHA.120.316770

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Article

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.

Circulation research - 6 Nov 2020

Depuydt Marie A C, Prange Koen H M, Slenders Lotte, Örd Tiit, Elbersen Danny, Boltjes Arjan, de Jager Saskia C A, Asselbergs Folkert W, de Borst Gert J, Aavik Einari, Lönnberg Tapio, Lutgens Esther, Glass Christopher K, den Ruijter Hester M, Kaikkonen Minna U, Bot Ilze, Slütter Bram, van der Laan Sander W, Yla-Herttuala Seppo, Mokry Michal, Kuiper Johan, de Winther Menno P J, Pasterkamp Gerard

Abstract excerpt

RATIONALE: Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed. OBJECTIVE: Using single-cell transcriptomics and chromatin accessibility, we gained a better understanding of the pathophysiology underlying human atherosclerosis. METHODS AND RESULTS: We performed single-cell RNA and single-cell ATAC sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32981416
DOI: 10.1161/CIRCRESAHA.120.316770
PMCID: PMC7641189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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