Article

Cell-type-specific polygenic risk scores reveal adipocyte-related interactions with lipids in coronary artery disease

2026-07-09

Abstract excerpt

<h4>Background</h4> Genome-wide polygenic risk scores (PRSs) for coronary artery disease (CAD) aggregate genetic effects across the genome and may obscure biologically distinct mechanisms. We aimed to develop cell-type-specific PRSs (csPRSs) using single-cell RNA sequencing (scRNA-seq) data and investigate their interactions with lipids on CAD risk. <h4>Methods</h4> Using publicly available scRNA-seq data from h...

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Literature Corpus work: 47bb276a-5f56-5b03-8cd1-2c3dfed2bad9
DOI: 10.64898/2026.07.07.26357510

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