Article

Dual states of Bmi1-expressing intestinal stem cells drive epithelial development and tissue regeneration

2022-10-01

Abstract excerpt

<h4>Summary</h4> Intestinal development, response to injury and disease states rely upon balanced stem cell proliferation. Historically, two subtypes of intestinal epithelial stem cells (ISCs)—slow-cycling/label-retaining, and actively-cycling/canonical Wnt-dependent—coordinate to drive proliferation and regulate epithelial renewal during adult tissue homeostasis and injury response. Recent studies focused on Bmi...

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Literature Corpus work: 02f486af-3722-5f55-bd3c-469dcc05e1f9
DOI: 10.1101/2022.09.30.509798

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