Article

Maternal obesity induces developmental programming of Intestinal stem cells through an IL-17A/PPAR immune-epithelial axis

2026-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Maternal obesity is associated with increased risk of sporadic colorectal cancer (CRC) in offspring, suggesting that early-life environmental exposures durably shape disease susceptibility. Intestinal stem cells (ISCs), long-lived drivers of epithelial renewal and tumor initiation, are well poised to mediate this effect; however, how maternal obesity influences ISC programming during development...

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Literature Corpus work: e49b34c8-f24d-5912-8e99-22a2f078c8fc
DOI: 10.64898/2026.03.15.711939

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