Article

Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis

2025-05-11

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) has limited treatments, and cell type-specific regulatory networks driving MASLD represent therapeutic avenues. We assayed five transcriptomic and epigenomic modalities in 2.4M cells from 86 livers across MASLD stages. Integrating modalities increased annotation of the genome in liver cell types several-fold over previous catalogs. We identified cell...

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Literature Corpus work: 4fcef3c1-e50d-5154-8c9d-e71cc9531265
DOI: 10.1101/2025.05.09.25327043

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