Article
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2016
Tolosa Laia, Gómez-Lechón M José, López Silvia, Guzmán Carla, Castell José V, Donato M Teresa, Jover Ramiro
Abstract excerpt
The capacity of human hepatic cell-based models to predict hepatotoxicity depends on the functional performance of cells. The major limitations of human hepatocytes include the scarce availability and rapid loss of the hepatic phenotype. Hepatoma cells are readily available and easy to handle, but are metabolically poor compared with hepatocytes. Recently developed human upcyte hepatocytes offer the advantage of...
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