Article

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

2024-10-29

Abstract excerpt

Accurate liver disease modeling and drug toxicity testing still remain challenging as liver cells in vitro poorly resemble adult hepatocytes, as we previously demonstrated using whole transcriptome and cell identity analysis. To address this, we used our insights into hepatic modeling to develop hepatocyte-like liver organoids (HeLLOs), a novel human organoid model with mature hepatocyte functions superior to exi...

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Literature Corpus work: fad2e88f-84a6-5751-898c-fa48492037de
DOI: 10.1101/2024.10.29.620824

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