Article

Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cells

2026-03-18

Abstract excerpt

<h4>Background</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is challenging to study in vivo in humans and in vitro models are limited. Although primary human hepatocytes (PHHs) are considered the gold-standard, immortalized hepatic cell lines are utilised due to scalability. This study compared the metabolic responses of PHHs with our Huh7-based model cultured in physiologically-relevan...

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Literature Corpus work: 7070bbd3-45cd-5b7e-bc8b-db89fd1bac19
DOI: 10.64898/2026.03.16.712092

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