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Article

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models.

Environment international - 1 Aug 2024

Alijagic Andi, Sinisalu Lisanna, Duberg Daniel, Kotlyar Oleksandr, Scherbak Nikolai, Engwall Magnus, Orešič Matej, Hyötyläinen Tuulia

Abstract excerpt

PFAS are ubiquitous industrial chemicals with known adverse health effects, particularly on the liver. The liver, being a vital metabolic organ, is susceptible to PFAS-induced metabolic dysregulation, leading to conditions such as hepatotoxicity and metabolic disturbances. In this study, we investigated the phenotypic and metabolic responses of PFAS exposure using two hepatocyte models, HepG2 (male cell line) and...

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Identifiers

PMID: 38906088
DOI: 10.1016/j.envint.2024.108820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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