Article

Pathway Coessentiality Mapping Reveals Complex II is Required for <i>de novo</i> Purine Biosynthesis in Acute Myeloid Leukemia

2025-03-02

Abstract excerpt

Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights 1,2 , but they miss the emergent properties of pathways working together. To address this challenge, we developed a multi-gene approach to pathway mapping and applied it to CRISPR...

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Literature Corpus work: fe7fb494-e60f-57d3-952a-373d2f276f59
DOI: 10.1101/2025.02.26.640463

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Pathway Coessentiality Mapping Reveals Complex II is Required for <i>de novo</i> Purine Biosynthesis in Acute Myeloid LeukemiaDOI 10.1101/2025.02.26.640463Read

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