Article
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Blood - 12 Apr 2018
Gallipoli Paolo, Giotopoulos George, Tzelepis Konstantinos, Costa Ana S H, Vohra Shabana, Medina-Perez Paula, Basheer Faisal, Marando Ludovica, Di Lisio Lorena, Dias Joao M L, Yun Haiyang, Sasca Daniel, Horton Sarah J, Vassiliou George, Frezza Christian, Huntly Brian J P
Abstract excerpt
FLT3 internal tandem duplication (FLT3ITD) mutations are common in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new-generation FLT3 tyrosine kinase inhibitors (TKI) have shown promising results, the outcome of FLT3ITD AML patients remains poor and demands the identification of novel, specific, and validated therapeutic targets for this highly aggressive AML subtype. Utilizing an...
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