Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations.

doi:10.1038/s41375-021-01318-x

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Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations.

Leukemia - 1 Oct 2021

Simonetti Giorgia, Mengucci Carlo, Padella Antonella, Fonzi Eugenio, Picone Gianfranco, Delpino Claudio, Nanni Jacopo, De Tommaso Rossella, Franchini Eugenia, Papayannidis Cristina, Marconi Giovanni, Pazzaglia Martina, Perricone Margherita, Scarpi Emanuela, Fontana Maria Chiara, Bruno Samantha, Tebaldi Michela, Ferrari Anna, Bochicchio Maria Teresa, Ghelli Luserna Di Rorà Andrea, Ghetti Martina, Napolitano Roberta, Astolfi Annalisa, Baldazzi Carmen, Guadagnuolo Viviana, Ottaviani Emanuela, Iacobucci Ilaria, Cavo Michele, Castellani Gastone, Haferlach Torsten, Remondini Daniel, Capozzi Francesco, Martinelli Giovanni

Abstract excerpt

Although targeting of cell metabolism is a promising therapeutic strategy in acute myeloid leukemia (AML), metabolic dependencies are largely unexplored. We aimed to classify AML patients based on their metabolic landscape and map connections between metabolic and genomic profiles. Combined serum and urine metabolomics improved AML characterization compared with individual biofluid analysis. At intracellular...

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Identifiers

PMID: 34193978
DOI: 10.1038/s41375-021-01318-x
PMCID: PMC8478658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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