Article
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
Nature communications - 19 Apr 2022
Erdem Ayşegül, Marin Silvia, Pereira-Martins Diego A, Geugien Marjan, Cunningham Alan, Pruis Maurien G, Weinhäuser Isabel, Gerding Albert, Bakker Barbara M, Wierenga Albertus T J, Rego Eduardo M, Huls Gerwin, Cascante Marta, Schuringa Jan Jacob
Abstract excerpt
Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular changes or in response to pathway-inhibiting drugs. Here, we uncover that AML patients with FLT3 internal tandem duplications (FLT3-ITD+) are characterized by a high expression of succinate-CoA ligases and...
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