Article

Mapping metabolic coevolution identifies c11orf54 as the missing pentose pathway decarboxylase.

2025-03-19

Abstract excerpt

<title>Abstract</title> <p>Metabolic networks and enzyme-molecule connections are still being elucidated. Here, through systematic analysis of gene loss and gain across the eukaryotic tree, mapped onto metabolic networks, we build a coevolutionary framework of human metabolism. Using this information, we identify unmapped genes in metabolic pathways, leading to the discovery of C11orf54 as the long-missing decarb...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82c1e4c9-9463-5bcd-ae3f-bebe03f28bde
DOI: 10.21203/rs.3.rs-6141043/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping metabolic coevolution identifies c11orf54 as the missing pentose pathway decarboxylase.DOI 10.21203/rs.3.rs-6141043/v1Read

A Next Generation Multiscale View of Inborn Errors of Metabolism.Semantic proximity Read

Integrated multi-omics reveals anaplerotic insufficiency in methylmalonyl-CoA mutase deficiencySemantic proximity Read

Pathway Coessentiality Mapping Reveals Complex II is Required for <i>de novo</i> Purine Biosynthesis in Acute Myeloid LeukemiaSemantic proximity Read

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mappingSemantic proximity Read

Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic ModelingSemantic proximity Read

Pan-cancer analysis of the metabolic reaction networkSemantic proximity Read

A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype.Semantic proximity Read

A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptakeSemantic proximity Read

The implications of human metabolic network topology for disease comorbidity.Semantic proximity Read

Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiotaSemantic proximity Read

Mapping the Landscape of Treatable Inborn Errors of Metabolism: A Systematic Gene-Level Evaluation Based on the ICIMD ClassificationSemantic proximity Read

Illuminating the functions of the understudied Fructosamine-3-kinase (FN3K) using a multi-omics approach reveals new links to lipid, carbon, and co-factor metabolic pathwaysSemantic proximity Read