Article

Porphyrin overdrive rewires pan-cancer cell metabolism

2022-02-19

Abstract excerpt

<h4>Porphyrin overdrive rewires pan-cancer cell metabolism</h4> All cancer cells reprogram metabolism to support aberrant growth. Here, we report that cancer cells employ and depend on imbalanced and dynamic heme metabolic pathways for their oncogenic growth. We coined this essential metabolic rewiring ‘porphyrin overdrive’ and determined that it is cancer-universal, cancer-essential, and cancer-specific. While p...

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Literature Corpus work: 21dd1731-b513-54a7-a4b1-14bd03d49f51
DOI: 10.1101/2022.02.18.481061

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