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datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mapping

2026-02-12

Abstract excerpt

<h4>ABSTRACT</h4> datadrivenhypothesis.org (DDH) integrates gene dependency, expression, literature data, and beyond from ∼20,000 human genes to reveal hidden metabolic connections. Through pathway-level co-essentiality analysis with novelty scoring, DDH uncovered unexpected links including Complex II coupled to purine nucleotide biosynthesis. This broad platform offers intuitive tools for hypothesis generation v...

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Literature Corpus work: 536ac1bf-2eba-5a53-8f79-f46bd8d265cf
DOI: 10.64898/2026.02.11.705287

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