Article

Global human myeloid replacement with peripheral progenitors induces interferonopathy and neurodegeneration

2025-10-03

Abstract excerpt

<title>Abstract</title> <p>Microglia, the brain’s resident macrophages, arise from yolk sac hematopoietic progenitor cells (HPCs) that migrate into the brain during early embryonic development and differentiate in response to microenvironment-specific signals. The resulting spatial and stage-specific programs of gene expression enable microglia to function as key modulators of diverse homeostatic processes that i...

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Literature Corpus work: d9b773d3-e7ee-5fc7-9369-d0e41a81e337
DOI: 10.21203/rs.3.rs-7762822/v1

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