Article
Origins of chromosome instability unveiled by coupled imaging and genomics.
Nature - 1 Dec 2025
Cosenza Marco Raffaele, Gaiatto Alice, Erarslan Uysal Büşra, Andrades Álvaro, Sautter Nina Luisa, Simunovic Marina, Jendrusch Michael Adrian, Zumalave Sonia, Rausch Tobias, Halavatyi Aliaksandr, Geissen Eva-Maria, Eigenmann Joshua Lucas, Weber Thomas, Hasenfeld Patrick, Benito Eva, Stober Catherine, Cortes-Ciriano Isidro, Kulozik Andreas E, Pepperkok Rainer, Korbel Jan O
Abstract excerpt
Somatic chromosome instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution1-3. Although CAs have been linked to mitotic errors resulting in the emergence of nuclear atypia4-7, the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence...
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