Article

Metagenomic strain-resolved DNA modification patterns link extrachromosomal genetic elements to host strains

2026-03-28

Abstract excerpt

DNA modification is central to microbial defense against extrachromosomal genetic elements (ECEs), consequently ECEs tend to adopt their host's modification patterns. Shared ECE-host modification patterns enable linking ECEs to their hosts, but modification detection tools are designed for single genomes and are ineffective at metagenome scale. Here, we present MODIFI, software for detecting DNA modifications in m...

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Literature Corpus work: fe6e15af-2572-5f12-bb5c-09787e314670
DOI: 10.64898/2026.03.27.714056

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