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Article

Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity.

FEMS microbiology reviews - 2 Jan 2026

Sharaf Sara, Cappelletti Martina, Oggioni Marco R, Hijazi Karolin

Abstract excerpt

DNA methyltransferases (DNA MTases) are central epigenetic regulators in bacteria and archaea, with functions extending far beyond classical restriction-modification defence. Diverse MTase classes exist, including canonical and phase-variable restriction-modification systems, orphan MTases, and enzymes with currently undefined roles. MTase activity is associated with regulatory outcomes through both direct and...

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Identifiers

PMID: 41874420
DOI: 10.1093/femsre/fuag014
PMCID: PMC13076061

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