Article

Epigenetic phase variation in the gut microbiome enhances bacterial adaptation

2025-01-12

Abstract excerpt

The human gut microbiome within the gastrointestinal tract continuously adapts to variations in diet, medications, and host physiology. A strategy for bacterial genetic adaptation is epigenetic phase variation (ePV) mediated by bacterial DNA methylation, which can regulate gene expression, enhance clonal heterogeneity, and enable a single bacterial strain to exhibit variable phenotypic states. Genome-wide and site...

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Literature Corpus work: 35e775c0-ffc1-51fe-8125-af1b6872b02c
DOI: 10.1101/2025.01.11.632565

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