Analyzing rare mutations in metagenomes assembled using long and accurate reads.

Abstract excerpt

The advent of long and accurate "HiFi" reads has greatly improved our ability to generate complete metagenome-assembled genomes (MAGs), enabling "complete metagenomics" studies that were nearly impossible to conduct with short reads. In particular, HiFi reads simplify the identification and phasing of mutations in MAGs: It is increasingly feasible to distinguish between positions that are prone to mutations and...

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