Article

GAGER: gene regulatory network assisted gene expression restoration

2024-12-02

Abstract excerpt

Gene regulatory networks are crucial for cellular function, and disruptions in transcription factor (TF) regulation often lead to diseases. However, identifying TFs to transition a source cell state to a desired target state remains challenging. We present a method to identify key TFs whose perturbation can restore gene expressions in a source state to target levels. Its effectiveness is demonstrated on datasets f...

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Literature Corpus work: fdc6d53b-7403-5fea-a4bd-aef8169dbd51
DOI: 10.1101/2024.11.27.625595

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