Article

Transfer of regulatory knowledge from human to mouse for functional genomic analysis

2019-01-29

Abstract excerpt

Transcriptome profiling followed by differential gene expression analysis often leads to unclear lists of genes which are hard to analyse and interpret. Functional genomic tools are powerful approaches for downstream analysis, as they summarize the large and noisy gene expression space in a smaller number of biological meaningful features. In particular, methods that estimate the activity of processes by mapping t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42df47cb-25ed-5474-873d-1ace62da9510
DOI: 10.1101/532739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transfer of regulatory knowledge from human to mouse for functional genomic analysisDOI 10.1101/532739Read

A Framework to Analyse and Interpret Mouse Functional Genome by Prioritizing High Impact SNPsSemantic proximity Read

Causal gene regulatory network inference using enhancer activity as a causal anchorSemantic proximity Read

GAGER: gene regulatory network assisted gene expression restorationSemantic proximity Read

The Transcription Factor Binding Landscape of Mouse DevelopmentSemantic proximity Read

Network- and enrichment-based inference of phenotypes and targets from large-scale disease maps.Semantic proximity Read

Perturbation-response genes reveal signaling footprints in cancer gene expressionSemantic proximity Read

MousiPLIER: A Mouse Pathway-Level Information Extractor ModelSemantic proximity Read

A genomewide functional network for the laboratory mouse.Semantic proximity Read

The future objectives of the International Mouse Phenotyping Consortium (IMPC): functional evaluation of human disease-relevant cis-regulatory elements in the mouse genome.Semantic proximity Read

Benchmark and integration of resources for the estimation of human transcription factor activitiesSemantic proximity Read

SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks.Semantic proximity Read

Large-scale, interpretable gene regulatory network inference through biologically informed matrix factorizationSemantic proximity Read