Article

Reference Regulatory Element-Guided Gene Expression Analysis for Mechanistic Inference of Gene Regulatory Networks

2026-07-16

Abstract excerpt

Regulatory genomics faces a depth–breadth gap: deep multi-omics provides regulatory detail but is difficult to scale, whereas broad expression datasets often lack the regulatory structure needed for mechanistic Gene Regulatory Network (GRN) analysis. We developed Regulatory Elements Guided Analysis (REGA), an interpretable framework that uses reference Regulatory Element (RE) catalogs to infer transcription factor...

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Literature Corpus work: 97fd1e03-8215-502c-a7a6-6baef7142f94
DOI: 10.64898/2026.07.10.737848

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