Article

Multimodal foundation model predicts zero-shot functional perturbations and cell fate dynamics

2024-12-22

Abstract excerpt

Deciphering cell type-specific perturbation effects on genes and cellular states demands considerable experimental resources. To overcome this challenge, we propose Perturbation Transformer (PertFormer), a foundation model to uncover functional and regulatory mechanisms through interpretable in silico perturbation process. PertFormer comprises 3 billion parameters pretrained on both bulk and single-cell datasets c...

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Literature Corpus work: 89c419d5-fd07-5255-a607-2ef53fd78b07
DOI: 10.1101/2024.12.19.629561

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