Article

Joint inference of transcription factor activity and context-specific regulatory networks

2022-12-14

Abstract excerpt

Transcriptional regulation is a critical process that determines cell fate and disease. One of the challenges in understanding transcriptional regulation is that there is no easy way to infer the main regulators from gene expression data. Many existing methods focus on estimating the activity of individual transcription factors (TFs) using static TF-gene interaction databases, but regulomes are often altered in di...

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Literature Corpus work: bfea32ac-6015-573a-85bf-f77803422e76
DOI: 10.1101/2022.12.12.520141

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