Article

Ablation of the Renal Tubular Gluconeogenic Enzyme PCK1 Drives AKI-to-CKD Transition by Negatively Regulating the TGF-β/Smad3 Signaling Pathway

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by progressive renal fibrosis, yet the metabolic drivers of this maladaptive repair remain inadequately defined. In this study, we investigated the role of phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme of gluconeogenesis, in the AKI-to-CKD transition. Analysis of human s...

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Literature Corpus work: fdb5d557-d314-552e-a8a6-cf3a4ebc3d7b
DOI: 10.21203/rs.3.rs-9202714/v1

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