Article

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

2024-10-18

Abstract excerpt

Kidney fibrosis, characterized by excessive extracellular matrix deposition, is a progressive disease that, despite affecting 10% of the population, lacks specific treatments and suitable biomarkers. This study presents a comprehensive, time-resolved multi-omics analysis of kidney fibrosis using an in vitro model system based on human kidney PDGFRβ+ mesenchymal cells aimed at unraveling disease mechanisms. Using t...

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Literature Corpus work: 58a82ad3-4b50-5268-8926-5137c70f2375
DOI: 10.1101/2024.10.15.618507

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