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Article

Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.

PloS one - 1 Jan 2016

Riwanto Meliana, Kapoor Sarika, Rodriguez Daniel, Edenhofer Ilka, Segerer Stephan, Wüthrich Rudolf P

Abstract excerpt

Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+), a chronic progressive model of PKD. Using microarray analysis and qPCR, we found an upregulation of genes involved...

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Source

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Identifiers

PMID: 26752072
DOI: 10.1371/journal.pone.0146654
PMCID: PMC4708993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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