Article

Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis

2022-10-31

Abstract excerpt

Renal fibrosis is the common pathological pathway of various chronic kidney diseases (CKD) in progression to the end stage of renal failure. Impaired renal gluconeogenesis has been recently identified as a hallmark of CKD. The role of gluconeogenesis in renal fibrosis is currently unknown. Through RNA sequencing and cleavage under targets and tagmentation (CUT&Tag) sequencing analysis, we found that the phosphoeno...

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Literature Corpus work: 10d0ca35-8b49-5055-9cd2-fc752228e799
DOI: 10.1101/2022.10.31.514497

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Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosisDOI 10.1101/2022.10.31.514497Read

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