Article

SPDEF promotes the classical subtype of pancreatic ductal adenocarcinoma

2022-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDA) samples reveal extensive cellular heterogeneity. Using single-cell RNA sequencing, we uncover multiple tumor cell populations distinguished by their differentiation state and associated with different stages of tumor progression in a mouse model of PDA. We identify Spdef as a factor required for tumorigenesis in pancreatic cancer cells of epithelial and muc...

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Literature Corpus work: 1ac003f8-c37d-5d36-9dab-fcc407730f9f
DOI: 10.1101/2022.03.18.484951

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