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CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing

8 Jan 2024

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective treatment options, potentiating the importance of uncovering novel drug targets. Here, we target cleavage and polyadenylation specificity factor 3 (CPSF3), the 3′ endonuclease that catalyzes mRNA cleavage during polyadenylation and histone mRNA processing. We find that CPSF3 is highly expressed in PDAC and is associated with poor...

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PMID: 38191171
DOI: 10.1261/rna.079931.123

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