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Article

Alternative Cleavage and Polyadenylation during Colorectal Cancer Development

9 Aug 2012

Abstract excerpt

PURPOSE: Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3'-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that altered APA contributes to progression of colorectal cancer, and that measurement of APA...

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PMID: 22874640
DOI: 10.1158/1078-0432.ccr-12-0543

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